{"id":894,"date":"2016-09-23T00:15:41","date_gmt":"2016-09-22T22:15:41","guid":{"rendered":"http:\/\/www.scivit.de\/lang\/?p=894"},"modified":"2016-09-23T00:15:41","modified_gmt":"2016-09-22T22:15:41","slug":"ca2-channels-and-their-inhibitors","status":"publish","type":"post","link":"https:\/\/www.scivit.de\/lang\/archive\/894","title":{"rendered":"Ca2+ channels and their inhibitors"},"content":{"rendered":"

[et_pb_section admin_label=“Sektion“ fullwidth=“on“ specialty=“off“][et_pb_fullwidth_image admin_label=“Volle Breite des Bildes“ src=“https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg“ alt=“Ca2+ channels and their inhibitors – Scivit News“ title_text=“Ca2+ channels and their inhibitors – Scivit News“ show_in_lightbox=“off“ url_new_window=“off“ use_overlay=“off“ animation=“left“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“] [\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section admin_label=“section“][et_pb_row admin_label=“Zeile“][et_pb_column type=“4_4″][et_pb_post_title admin_label=“Posttitel“ title=“on“ meta=“on“ author=“on“ date=“on“ categories=“on“ comments=“on“ featured_image=“off“ featured_placement=“below“ parallax_effect=“on“ parallax_method=“on“ text_orientation=“left“ text_color=“dark“ text_background=“off“ text_bg_color=“rgba(255,255,255,0.9)“ module_bg_color=“rgba(255,255,255,0)“ title_all_caps=“off“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“] [\/et_pb_post_title][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=“row“][et_pb_column type=“4_4″][et_pb_text admin_label=“Summary“ background_layout=“light“ text_orientation=“left“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“ text_font=“|on|||“ text_font_size=“18″]<\/p>\n

Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their activity decreases blood pressure by decreasing contraction of blood vessel smooth muscle cells. Similarly, arrhythmic contractions of the heart muscle are treated by blocking Ca2+ channels. Different compounds are used for treating high blood pressure (1,4-dihydropyridines) and arrhythmias (phenylalkylamines, benzothiazepines) and it has been suggested that these compounds bind at different sites of Ca2+ channels. Crystallographic analysis of wild type and mutated Ca2+ channels by scientists from Great Britain and the US now defined precise binding sites and modes of action for the various compounds.
\n<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=“row“ make_fullwidth=“off“ use_custom_width=“off“ width_unit=“on“ use_custom_gutter=“off“ padding_mobile=“off“ allow_player_pause=“off“ parallax=“off“ parallax_method=“off“ make_equal=“off“ parallax_1=“off“ parallax_method_1=“off“ column_padding_mobile=“on“][et_pb_column type=“4_4″][et_pb_text admin_label=“Text“ background_layout=“light“ text_orientation=“left“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“ text_font_size=“18″]<\/p>\n

For their studies scientists used a bacterial homotetrameric model channel. Br-verapamil, representing phenylalkylamines, bound within the channel pore on the cytoplasmic side of the selectivity filter, this way blocking the pore (see figure). Compounds representing dihydropyridines, on the other hand, bound to an external surface of the channel exposed to membrane lipids. This resulted in allosteric changes in channel conformation, blocking the central pore.<\/span><\/p>\n

The figure above shows binding of Br-verapamil to the homotetrameric bacterial channel. Br-verapamil is given in blue colour.<\/p>\n

Source: Tang et al., Nature 537, 117 \u2013 122<\/a><\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=“row“ make_fullwidth=“off“ use_custom_width=“off“ width_unit=“on“ use_custom_gutter=“off“ padding_mobile=“off“ allow_player_pause=“off“ parallax=“off“ parallax_method=“off“ make_equal=“off“ parallax_1=“off“ parallax_method_1=“off“ column_padding_mobile=“on“][et_pb_column type=“4_4″][et_pb_text admin_label=“Links“ background_layout=“light“ text_orientation=“left“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“ text_font_size=“18″]<\/p>\n

Scivit News – Visual Science<\/a><\/p>\n

More illustrations from Scivit<\/a><\/p>\n

Videos from Scivit<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=“Zeile“ global_module=“619″ make_fullwidth=“off“ use_custom_width=“off“ width_unit=“on“ use_custom_gutter=“off“ padding_mobile=“off“ allow_player_pause=“off“ parallax=“off“ parallax_method=“off“ make_equal=“off“ parallax_1=“off“ parallax_method_1=“off“ column_padding_mobile=“on“][et_pb_column type=“4_4″][et_pb_post_nav global_parent=“619″ admin_label=“Beitragsnavigierung“ in_same_term=“off“ hide_prev=“off“ hide_next=“off“ prev_text=“Previous News“ next_text=“Further News“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“ title_font_size=“18px“] [\/et_pb_post_nav][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

[et_pb_section admin_label=“Sektion“ fullwidth=“on“ specialty=“off“][et_pb_fullwidth_image admin_label=“Volle Breite des Bildes“ src=“https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg“ alt=“Ca2+ channels and their inhibitors – Scivit News“ title_text=“Ca2+ channels and their inhibitors – Scivit News“ show_in_lightbox=“off“ url_new_window=“off“ use_overlay=“off“ animation=“left“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“] [\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section admin_label=“section“][et_pb_row admin_label=“Zeile“][et_pb_column type=“4_4″][et_pb_post_title admin_label=“Posttitel“ title=“on“ meta=“on“ author=“on“ date=“on“ categories=“on“ comments=“on“ featured_image=“off“ featured_placement=“below“ parallax_effect=“on“ parallax_method=“on“ text_orientation=“left“ text_color=“dark“ text_background=“off“ text_bg_color=“rgba(255,255,255,0.9)“ module_bg_color=“rgba(255,255,255,0)“ title_all_caps=“off“ use_border_color=“off“ border_color=“#ffffff“ […]<\/p>\n","protected":false},"author":1,"featured_media":895,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[19,11,10,7],"tags":[],"class_list":["post-894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biochemistry","category-medicine","category-structure","category-news"],"jetpack_publicize_connections":[],"yoast_head":"\nCa2+ channels and their inhibitors - Scivit News<\/title>\n<meta name=\"description\" content=\"Ca2+ channels and their inhibitors - Scivit News: Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.scivit.de\/lang\/archive\/894\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ca2+ channels and their inhibitors - Scivit News\" \/>\n<meta property=\"og:description\" content=\"Ca2+ channels and their inhibitors - Scivit News: Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.scivit.de\/lang\/archive\/894\" \/>\n<meta property=\"og:site_name\" content=\"Scivit - english version\" \/>\n<meta property=\"article:published_time\" content=\"2016-09-22T22:15:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"694\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Thomas Fester\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Thomas Fester\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"3\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.scivit.de\/lang\/archive\/894\",\"url\":\"https:\/\/www.scivit.de\/lang\/archive\/894\",\"name\":\"Ca2+ channels and their inhibitors - Scivit News\",\"isPartOf\":{\"@id\":\"https:\/\/www.scivit.de\/lang\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.scivit.de\/lang\/archive\/894#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.scivit.de\/lang\/archive\/894#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg\",\"datePublished\":\"2016-09-22T22:15:41+00:00\",\"author\":{\"@id\":\"https:\/\/www.scivit.de\/lang\/#\/schema\/person\/67543e56f1eaa2eac9b8c1723c730186\"},\"description\":\"Ca2+ channels and their inhibitors - Scivit News: Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their\",\"breadcrumb\":{\"@id\":\"https:\/\/www.scivit.de\/lang\/archive\/894#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.scivit.de\/lang\/archive\/894\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.scivit.de\/lang\/archive\/894#primaryimage\",\"url\":\"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg\",\"contentUrl\":\"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg\",\"width\":1600,\"height\":694,\"caption\":\"Ca2+ channels and their inhibitors - Scivit News\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.scivit.de\/lang\/archive\/894#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.scivit.de\/lang\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ca2+ channels and their inhibitors\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.scivit.de\/lang\/#website\",\"url\":\"https:\/\/www.scivit.de\/lang\/\",\"name\":\"Scivit - english version\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.scivit.de\/lang\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.scivit.de\/lang\/#\/schema\/person\/67543e56f1eaa2eac9b8c1723c730186\",\"name\":\"Thomas Fester\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.scivit.de\/lang\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/a778df5d3fa3840fc931ac5769b51060?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/a778df5d3fa3840fc931ac5769b51060?s=96&d=mm&r=g\",\"caption\":\"Thomas Fester\"},\"url\":\"https:\/\/www.scivit.de\/lang\/archive\/author\/thomas-fester\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ca2+ channels and their inhibitors - Scivit News","description":"Ca2+ channels and their inhibitors - Scivit News: Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.scivit.de\/lang\/archive\/894","og_locale":"de_DE","og_type":"article","og_title":"Ca2+ channels and their inhibitors - Scivit News","og_description":"Ca2+ channels and their inhibitors - Scivit News: Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their","og_url":"https:\/\/www.scivit.de\/lang\/archive\/894","og_site_name":"Scivit - english version","article_published_time":"2016-09-22T22:15:41+00:00","og_image":[{"width":1600,"height":694,"url":"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg","type":"image\/jpeg"}],"author":"Thomas Fester","twitter_card":"summary_large_image","twitter_misc":{"Verfasst von":"Thomas Fester","Gesch\u00e4tzte Lesezeit":"3\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.scivit.de\/lang\/archive\/894","url":"https:\/\/www.scivit.de\/lang\/archive\/894","name":"Ca2+ channels and their inhibitors - Scivit News","isPartOf":{"@id":"https:\/\/www.scivit.de\/lang\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.scivit.de\/lang\/archive\/894#primaryimage"},"image":{"@id":"https:\/\/www.scivit.de\/lang\/archive\/894#primaryimage"},"thumbnailUrl":"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg","datePublished":"2016-09-22T22:15:41+00:00","author":{"@id":"https:\/\/www.scivit.de\/lang\/#\/schema\/person\/67543e56f1eaa2eac9b8c1723c730186"},"description":"Ca2+ channels and their inhibitors - Scivit News: Voltage-gated Ca2+ channels are important in initiating contraction of muscle cells. A reduction of their","breadcrumb":{"@id":"https:\/\/www.scivit.de\/lang\/archive\/894#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.scivit.de\/lang\/archive\/894"]}]},{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.scivit.de\/lang\/archive\/894#primaryimage","url":"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg","contentUrl":"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg","width":1600,"height":694,"caption":"Ca2+ channels and their inhibitors - Scivit News"},{"@type":"BreadcrumbList","@id":"https:\/\/www.scivit.de\/lang\/archive\/894#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.scivit.de\/lang\/"},{"@type":"ListItem","position":2,"name":"Ca2+ channels and their inhibitors"}]},{"@type":"WebSite","@id":"https:\/\/www.scivit.de\/lang\/#website","url":"https:\/\/www.scivit.de\/lang\/","name":"Scivit - english version","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.scivit.de\/lang\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Person","@id":"https:\/\/www.scivit.de\/lang\/#\/schema\/person\/67543e56f1eaa2eac9b8c1723c730186","name":"Thomas Fester","image":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.scivit.de\/lang\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a778df5d3fa3840fc931ac5769b51060?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a778df5d3fa3840fc931ac5769b51060?s=96&d=mm&r=g","caption":"Thomas Fester"},"url":"https:\/\/www.scivit.de\/lang\/archive\/author\/thomas-fester"}]}},"jetpack_featured_media_url":"https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/09\/CavabLang.jpg","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7rKfL-eq","_links":{"self":[{"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/posts\/894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/comments?post=894"}],"version-history":[{"count":2,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/posts\/894\/revisions"}],"predecessor-version":[{"id":897,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/posts\/894\/revisions\/897"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/media\/895"}],"wp:attachment":[{"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/media?parent=894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/categories?post=894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.scivit.de\/lang\/wp-json\/wp\/v2\/tags?post=894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}