{"id":1229,"date":"2016-12-10T00:17:42","date_gmt":"2016-12-09T23:17:42","guid":{"rendered":"http:\/\/www.scivit.de\/lang\/?p=1229"},"modified":"2016-12-10T00:17:42","modified_gmt":"2016-12-09T23:17:42","slug":"gene-specific-correlation-of-rna-and-protein-levels-in-human-cells-and-tissues","status":"publish","type":"post","link":"https:\/\/www.scivit.de\/lang\/archive\/1229","title":{"rendered":"Gene-specific correlation of RNA and protein levels in human cells and tissues"},"content":{"rendered":"

[et_pb_section admin_label=“Sektion“ fullwidth=“on“ specialty=“off“][et_pb_fullwidth_image admin_label=“Volle Breite des Bildes“ src=“https:\/\/www.scivit.de\/lang\/wp-content\/uploads\/2016\/12\/Teaserb-2.jpg“ alt=“Protein levels can be deduced from transcript levels“ title_text=“Protein levels can be deduced from transcript levels“ show_in_lightbox=“off“ url_new_window=“off“ use_overlay=“off“ animation=“left“ use_border_color=“on“ border_color=“#0c71c3″ border_style=“solid“ border_width=“2px“] [\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section admin_label=“section“][et_pb_row admin_label=“Zeile“][et_pb_column type=“4_4″][et_pb_post_title admin_label=“Posttitel“ title=“on“ meta=“on“ author=“on“ date=“on“ categories=“on“ comments=“on“ featured_image=“off“ featured_placement=“below“ parallax_effect=“on“ parallax_method=“on“ text_orientation=“left“ text_color=“dark“ text_background=“off“ text_bg_color=“rgba(255,255,255,0.9)“ module_bg_color=“rgba(255,255,255,0)“ title_all_caps=“off“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“] [\/et_pb_post_title][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=“Zeile“][et_pb_column type=“4_4″][et_pb_text admin_label=“Text“ background_layout=“light“ text_orientation=“left“ use_border_color=“off“ border_color=“#ffffff“ border_style=“solid“ text_font_size=“18″]<\/p>\n

Transcriptomics does have some significance after all.<\/h3>\n

It is considerably easier to determine shifts in transcript levels when compared to shifts in protein levels. But how significant are such shifts? Transcripts are only units of information, they have hardly any direct effects. Can we deduce changes on the protein levels from shifts in transcript levels? This question has been contentious for a very long time; according to Edfors and colleagues it is possible to use transcript levels as proxies for protein levels as long as we refer to individual proteins. In this case relations between transcript and protein levels were relatively stable when comparing different human tissues or cell lines. When comparing different genes, however, we have to be aware that transcript\/protein-levels may vary over a wide range (200 \u2013 220 000).<\/p>\n

Source:\u00a0 Edfors et al., Molecular Systems Biology 12: 883<\/a><\/p>\n

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