Spiral protein disaggregase – Gif animation

von | Sep 15, 2016 | Biochemistry, Molecular Structures, News | 0 Kommentare


Protein disaggregation by a spiral enzyme

The animated gif shows a short trip across the inner space of the yeast Hsp 104 AAA+ protein disaggregase. Unlike other, ring-like  AAA+ protein disaggregase, the hexameric Hsp104 forms a large helical structure. ATP-binding sites are lining the central space of the hexamer, probably corresponding to the actual path of the substrate polypeptide.