Proteins soluble in water in general contain hydrophobic amino acids in the internal, core regions and hydrophilic amino acids in their periphery where they can interact with water molecules. This phenomenon is visualized here using the cellulase introduced recently. In the following images only the side chains of amino acid are shown. Hydrophobic residues are given in white color, hydrophilic ones in blue. The artificial substrate cocrystallized with the cellulase is given in yellow.
Hydrophobic core